Acharya Prashant explains the spiritual symbolism of wine as divine joy that overpowers the thinking mind and removes cleverness. He clarifies that the wine mentioned in spiritual verses represents a life of joy, free from worries and tensions, which is distinct from mere pleasure. To attain this wine, one must be willing to drink their own blood, which signifies the sacrifice of body identification and the willingness to endure suffering or wounds for the sake of truth. He emphasizes that those who fear being hurt or bleeding cannot access this divine state, as the ego must be offered to receive the intoxication of the divine.