Acharya Prashant explains that the self cannot be known as an object of knowledge because our tools of measurement are flawed. He asserts that what we typically call 'knowing' is limited to things that are unstable, unreliable, and subject to change, such as our address, friends, or thoughts. Since everything in our knowledge pool can disappear, relying on it only leads to worry and insecurity. He challenges the audience to find one thing in their knowledge that is truly permanent, noting that even the most cherished relationships, like those with children or parents, cannot provide total security or fulfill all expectations.