Acharya Prashant explains that the ultimate remedy for suffering is the inquiry into the self and the world. He states that all suffering originates from the world and one's relationship with objects or people. By inquiring into both the subject (the 'I') and the object (the world), the duality between the two dissolves, leading to non-dual truth and freedom from the ego. He emphasizes that liberation is not found in the 'beyond' but through a deep examination of one's daily life, actions, and thoughts. The speaker asserts that truth is the only method and it requires total surrender, which begins when one recognizes the futility of their own cleverness and planning. This honesty about one's current state may bring initial disappointment, but such disappointment is considered auspicious as it leads to letting go of false hopes and entering into true spirituality.