Acharya Prashant discusses the importance of self-knowledge over mere objective knowledge, referencing the Upanishads and the Bhagavad Gita. He explains that while objective knowledge, or 'avidya', is necessary for understanding facts and the world, it leads to darkness if pursued without knowing the 'knower'. He defines 'avidya' as objective knowledge that often serves the human ego's desire for pleasure and consumption. He argues that without self-awareness, even the most advanced scientific discoveries are ultimately used for animalistic tendencies and physical gratification.